Revista da Associacao Medica Brasileira (1992)
-
Rev Assoc Med Bras (1992) · Apr 2021
Examination of clinical data and semen analysis results of patients undergoing orchiectomy for testicular tumor.
Testicular tumor constitutes 1% of male neoplasms. Infertility can be determined in patients with testicular tumors before orchiectomy due to the deterioration of spermatogenesis. The aim of this study was to show the clinical, radiological, and pathological characteristics and spermiogram results of patients with testicular tumor and their relationship with each other. ⋯ Spermatogenesis adversely affected before the treatment due to local and systemic effects of testicular cancer. Fertility expectations can be increased in the subsequent years by semen analysis and referral to cryopreservation.
-
Rev Assoc Med Bras (1992) · Apr 2021
IARS2 regulates proliferation, migration, and angiogenesis of human umbilical vein endothelial cells.
In this study, we aimed at investigating the role of isoleucyl-tRNA synthetase in the growth, migration, and angiogenesis of human umbilical vein endothelial cells and the underlying molecular mechanism. ⋯ We have shown, for the first time, the critical role of isoleucyl-tRNA synthetase in human umbilical vein endothelial cells. Our data show that isoleucyl-tRNA synthetase knockdown suppresses human umbilical vein endothelial cell proliferation, migration, and angiogenesis. We have also shown that isoleucyl-tRNA synthetase knockdown suppresses phosphorylation of extracellular-regulated kinase ½ and protein-serine- threonine kinase, as well as expression of vascular endothelial growth factor, GSK-3β, and β-catenin. Together, these data highlight isoleucyl-tRNA synthetase as a potential antitumor anti-angiogenic target.
-
Rev Assoc Med Bras (1992) · Apr 2021
Investigation of patients with coronary slow flow in terms of periodontal health status.
This study aims to evaluate the relationship between periodontal health status and coronary slow flow phenomenon. ⋯ Periodontitis might be accepted as one of the underlying causes of coronary slow flow. Patients with coronary slow flow should be evaluated for an underlying periodontal disease, and treatment of periodontal disease can protect against future cardiovascular events.