Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Jun 2014
Blood glucose as a marker of venous thromboembolism in critically ill children.
The ability to predict the development of venous thromboembolism is highly desirable. ⋯ Hyperglycemia is associated with venous thromboembolism in critically ill non-diabetic children. Maximum blood glucose is a potential predictor of venous thromboembolism in this population.
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J. Thromb. Haemost. · Jun 2014
Effect of recombinant ADAMTS-13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage.
A common complication after aneurysmal subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI), which is associated with vasospasm and other mechanisms such as microthrombosis. ADAMTS-13 activity plays a role in the prevention of thrombus formation in the cerebral microvasculature. Previously, we observed that patients with DCI have lower levels of ADAMTS-13. ⋯ Our results support the further study of rADAMTS-13 as a treatment option for the prevention of microthrombosis and brain injury after SAH.
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J. Thromb. Haemost. · Jun 2014
Systemic inhibition and liver-specific over-expression of PAI-1 failed to improve survival in all-inclusive populations or homogenous cohorts of CLP mice.
The role of plasminogen activator inhibitor type-1 (PAI-1) in abdominal sepsis remains elusive. ⋯ Restoration of fibrinolysis in early abdominal sepsis was not beneficial and it may prove detrimental in subjects with the lowest risk of death, while preemptive PAI-1 up-regulation at the current magnitude was not protective.