Journal of the Chinese Medical Association : JCMA
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Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by keratoconjunctivitis sicca, xerostomia, and extraglandular abnormalities. The precise etiology remains unclear. Previous studies have revealed that the apoptosis played an important role in the pSS. Herein, we investigated the expression and effect of second mitochondria-derived activator of caspase (Smac) in patients with pSS and associated the expression with clinicopathological parameters. ⋯ Smac plays an important role in the development of pSS.
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The current study aims to compare the variability of positional control of the club in the starting period of downswing and the orientation of the clubface during impact in elite and intermediate golfers. ⋯ These findings proposed a biomechanical approach of a practical way to observe swing behaviors. These findings suggest that the stability of locations of turning points is a golden reference for differentiating levels of golfers' performance.
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Meconium aspiration syndrome (MAS) is a major cause of severe respiratory failure in near- and full-term neonates. Alleviating inflammation is key to successfully treating severe MAS. Phosphodiesterase (PDE) inhibitors are known to play a role in airway smooth muscle relaxation and alveolar inflammation inhibition. This study aimed to investigate the effects of various intravenous (IV) PDE inhibitors and corticosteroids on MAS. ⋯ Using IV corticosteroids or any type of PDE inhibitors has some beneficial effects in improving oxygenation in MAS. PDE inhibitors are not superior to IV corticosteroids; in fact, adverse cardiovascular effects occur with the phosphodiesterase type 4 (PDE4) inhibitor. Further investigations are required before using IV corticosteroids and PDE inhibitors in future clinical application.