Emergency medicine Australasia : EMA
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Emerg Med Australas · Oct 2006
Development and implementation of an education and credentialing programme to provide safe paediatric procedural sedation in emergency departments.
In the conduct of paediatric procedural sedation (PPS) within the ED the combination of powerful drugs, variable competency levels and high staff turnover carry the potential for sedation-associated adverse events. Yet, currently, there is no set programme for education and accreditation of ED staff in PPS. We set out to develop such a programme. ⋯ We present the development and implementation of a comprehensive PPS programme for emergency staff. As a result of the multicentre development process involving a community and a tertiary paediatric ED the programme will likely have broad applicability in different types of ED caring for children.
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Emerg Med Australas · Aug 2006
Practice GuidelineCompressions: Australian Resuscitation Council Guideline 2006.
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Emerg Med Australas · Aug 2006
Comparative Study Clinical TrialComparative pharmacokinetics of Panadol Extend and immediate-release paracetamol in a simulated overdose model.
Panadol Extend is a modified-release paracetamol formulation in which each 665 mg tablet contains 69% slow-release and 31% immediate-release paracetamol. There are no data on Panadol Extend pharmacokinetics in overdose. It is unknown whether the paracetamol treatment nomogram can be used to make decisions regarding the toxicity of this product in overdose. ⋯ Reductions in Panadol Extend Cmax and AUC(0-12 h) might be related to elimination occurring during the absorption phase. In this model of Panadol Extend moderate overdose, Tmax was significantly delayed. In larger overdoses, time to peak paracetamol levels might be further delayed, because of continuing absorption from the formulation. Therefore, the paracetamol treatment nomogram might not reliably predict hepatotoxicity from Panadol Extend if paracetamol levels are measured too early.