The Journal of bone and joint surgery. American volume
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J Bone Joint Surg Am · Feb 2008
ReviewTissue engineering of bone: material and matrix considerations.
When the normal physiologic reaction to fracture does not occur, such as in fracture nonunions or large-scale traumatic bone injury, surgical intervention is warranted. Autografts and allografts represent current strategies for surgical intervention and subsequent bone repair, but each possesses limitations, such as donor-site morbidity with the use of autograft and the risk of disease transmission with the use of allograft. Synthetic bone-graft substitutes, developed in an effort to overcome the inherent limitations of autograft and allograft, represent an alternative strategy. ⋯ Depending on the specific application of the matrix, certain materials may be more or less well suited to the final structure; these include polymers, ceramics, and composites of the two. Each category is represented by matrices that can form either solid preformed structures or injectable forms that harden in situ. This article discusses the myriad design considerations that are relevant to successful bone repair with tissue-engineered matrices and provides an overview of several manufacturing techniques that allow for the actualization of critical design parameters.
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J Bone Joint Surg Am · Feb 2008
ReviewFracture repair with ultrasound: clinical and cell-based evaluation.
Fracture repair continues to be widely investigated, both within the clinical realm and at the fundamental research level, in part due to the fact that 5% to 10% of fractures result in either delayed union or nonunion, depending on the duration of incomplete healing. Beyond the temporal delay in repair, nonunions share the same unifying characteristic: all periosteal and endosteal repair processes have stopped and the fracture will not heal without surgical intervention. A less-invasive alternative method--low-intensity pulsed ultrasound--has shown promise as a treatment for delayed unions and nonunions and as a method to facilitate distraction osteogenesis. ⋯ The considerable amount of information that has been revealed about the behavior of osteoblasts under low-intensity pulsed ultrasound exposure suggests that the exact mechanism of action is complex. It is clear, however, that considerable progress is being made toward uncovering these mechanisms, which has served to encourage the use of low-intensity pulsed ultrasound in new applications. It is posited that successful noninvasive treatment strategies such as low-intensity pulsed ultrasound may be combined with other conventional and novel tissue-regeneration strategies to develop new treatments for large-scale bone defects.