The Journal of bone and joint surgery. American volume
-
J Bone Joint Surg Am · Nov 2013
CommentDoes tranexamic acid reduce blood loss in total knee arthroplasty? Commentary on an article by X. Aguilera, MD, et al.:"Efficacy and safety of fibrin glue and tranexamic acid to prevent postoperative blood loss in total knee arthroplasty. A randomized controlled clinical trial".
-
J Bone Joint Surg Am · Nov 2013
Randomized Controlled TrialTopical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total knee replacement: a randomized controlled trial (TRANX-K).
Approximately one-third of patients undergoing total knee replacement require one to three units of blood postoperatively. Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that has been successfully used intravenously to stop bleeding after total knee replacement. A topical application is easy to administer, provides a maximum concentration of tranexamic acid at the bleeding site, and is associated with little or no systemic absorption of the tranexamic acid. ⋯ Therapeutic level I. See Instructions for Authors for a complete description of levels of evidence.
-
J Bone Joint Surg Am · Nov 2013
Randomized Controlled Trial Multicenter Study Comparative StudyOne-to-one therapy is not superior to group or home-based therapy after total knee arthroplasty: a randomized, superiority trial.
The aim of this study was to determine whether center-based, one-to-one physical therapy provides superior outcomes compared with group-based therapy or a simple monitored home-based program in terms of functional and physical recovery and health-related quality of life after total knee arthroplasty. ⋯ Therapeutic level I. See Instructions for Authors for a complete description of levels of evidence.
-
J Bone Joint Surg Am · Nov 2013
Randomized Controlled TrialTopical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H).
Approximately one-third of patients undergoing total hip replacement surgery require one to three units of blood postoperatively. Tranexamic acid is a synthetic antifibrinolytic agent that has been successfully used intravenously to control bleeding after total hip replacement. A topical application is easy to administer, provides a maximum concentration of tranexamic acid at the bleeding site, and is associated with little or no systemic absorption of the tranexamic acid. ⋯ Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.