Acta neurochirurgica
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Acta neurochirurgica · Jan 1976
Dynamic changes in cerebrospinal fluid pressure during neurosurgical operations.
The effects of hyperventilation, osmotic and diuretic agents (urea, frusemide), thiopentone and succinylcholine chloride on the intracranial pressure were studied in neurosurgical patients with brain tumours. We have shown that hyperventilation together with osmotic and diuretic agents is very useful for reducing increased intracranial pressure.
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Acta neurochirurgica · Jan 1976
Effects of trimethaphan and sodium nitroprusside on cerebral blood flow in rhesus monkeys.
In tranquilised spontaneously breathing rhesus monkeys we have found that trimethaphan can reduce systemic blood pressure by 20% with little or no change in CBF. This was in marked contrast to those given nitroprusside which showed signs of loss of autoregulation at a 5% MBP reduction. It is our opinion that the divergence of these results from other work might be explained in part by differing anaesthetic techniques and species variations. On this experience we would be hesitant to use sodium nitroprusside or a hypotensive agent in any patient where cerebral blood flow might be already compromised.
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Acta neurochirurgica · Jan 1975
The relation between intracrainal pressure, mean arterial pressure and cerebral blood flow in patients with severe head injury.
In patients with severe head injuries ICP, MAP and CBF were measured continuously. In most patients there was a positive vasopressor response to increasing ICP, but the ICP/MAP ratio varied considerably in individual cases. CBF was diminished either by increasing ICP or by decreasing MAP. This effect was more marked with ICP above 40 mm Hg or MAP below 110 mm Hg. In terminal stages there was often a negative MAP/ICP ratio accompanied by massive cerebral hyperaemia. Key words: Severe head injury--intracranial pressure--mean arterial pressure--cerebral blood flow--cerebral perfusion pressure--critical limit of ICP and CBF. ⋯ ICP equals intracranial pressure (mm Hg); CBF, Flow equals cerebral blood flow (ml/min); MAP equals mean arterial pressure (mm Hg); CPP equals cerebral perfusion pressure (mm Hg) (difference between MAP and ICP); BP equals blood pressure.