Kathmandu University medical journal (KUMJ)
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Varenicline, a partial agonist of alpha4beta2 nicotinic acetylcholine receptor (nAChR), is the most recently approved drug for smoking cessation. Despite the availability of effective treatments for smoking cessation, such as nicotine replacement therapy and Bupropion sustained-release, abstinence rates remain less than optimal. ⋯ Clinical trials have demonstrated superior efficacy of this drug over Bupropion-SR for achieving abstinence from smoking, and Varenicline has also been shown to significantly delay smoking relapse. As the latest agent approved for smoking cessation, the mechanism of action, efficacy, and safety of Varenicline has been reviewed in this paper.
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Kathmandu Univ Med J (KUMJ) · Apr 2009
Comparative StudyComparative attitude and plans of the medical students and young Nepalese doctors.
Many doctors are leaving Nepal to work abroad. To understand this problem better, we decided to study the attitude and plans of young doctors and medical students. ⋯ Although majority of students, interns and house officers were of the opinion that a doctor's service to his community/country was very important, almost half of them still planned to migrate to a developed country after graduation. Improving the chances of professional advancement and professional working environment can make the profession more attractive, and therefore, may decrease this tendency for brain drain from our country.
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Kathmandu Univ Med J (KUMJ) · Jan 2009
Randomized Controlled TrialIntraperitoneal and periportal injection of bupivacaine for pain after laparoscopic cholecystectomy.
To study the analgesic efficacy of intraperitoneal and periportal injection of bupivacaine following laparoscopic cholecystectomy. ⋯ Intraperitoneal and periportal injection of bupivacaine is effective in decreasing pain after laparoscopic cholecystectomy.
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Kathmandu Univ Med J (KUMJ) · Jan 2009
Historical ArticleDevelopment of medical education in Nepal.
The first institution for training health workers started 75 years ago. Further development of teaching/learning institutions, mainly governmental started from the middle of the 20th Century. ⋯ This is possibly because of the huge demand of human resources of health (HRH) not only in Nepal, but worldwide. Various grades of HRH are going out of the country and seeking their livelihood elsewhere.
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Kathmandu Univ Med J (KUMJ) · Jan 2009
Editorial Historical ArticleMedical education: historical perspective.