Journal of neurosurgery. Spine
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Patients undergoing epidural injection for labor pains occasionally sustain iatrogenic inadvertent puncture of the dura with or without damage to the underlying neurological structures. This may be associated with CSF leakage, headache, neurological deficit, and infection. Rarely, the headache persists for years. ⋯ The authors recommend early MR imaging of the spine for any persisting headache that has a history of attempted spinal access. If an acquired spinal meningocele collection is found, exploration with a view to complete removal of the sac should be considered. To the authors' knowledge, this is the first case report depicting a rare, treatable cause of chronic spinal hypotension resulting in headaches.
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This was a retrospective clinical study in which the follow-up period exceeded 2 years. The authors investigated the time course of radiographic changes in the cervical range of motion (ROM) and sagittal alignment after cervical total disc replacement involving the ProDisc-C artificial disc. ⋯ In the early phase after ProDisc-C replacement, the ROM of the entire neck as well as functional and adjacent segments decreased but, at the late phase, they returned to the preoperative state. Contributions of functional and adjacent segments to whole-neck motion were not changed after ProDisc-C replacement. Adjacent-segmental motion could be saved by ProDisc-C replacement instead of interbody cage fusion. Segmental degenerative kyphosis was significantly corrected in patients who underwent ProDisc-C replacement.
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The pedicle screw has been reported to provide the strongest fixation for the cervical spine, but there is a possibility of malpositioning the screws, which may cause fatal complications such as vertebral artery and neural injuries. Using the conventional freehand technique, between 6.7 and 29% of the screws have been found to be malpositioned. If an accurate entry point and insertion trajectory through the isthmus of the pedicle can be maintained during surgery, safer insertion of the pedicle screw should be achieved. The authors have developed a new pedicle screw insertion method, called the "CT cutout" technique, and report on the technical and clinical aspects of this new technique in terms of accuracy. ⋯ Several techniques for pedicle screw insertion such as computer-assisted navigation, CT-based navigation, and acquisition of fluoroscopic intraoperative pedicle axis views have been used for improving accuracy. However, there remains a possibility of misplacement, and these costly procedures often require delivery of a high x-ray dose to both patients and surgeons, and/or time-consuming configuration of reference points during surgery. The CT cutout technique is an easy, low-cost procedure that can be performed with the aid of single-plane fluoroscopy and without the need of configuration. This new technique shows great promise for safe pedicle screw insertion for the cervical spine.
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After spinal cord injury (SCI) leukocytes infiltrate the injured cord, causing significant damage and further impairment of functional recovery. The leukocyte integrin alpha4beta1 is crucial for their entry. The authors previously demonstrated that an anti-alpha4 monoclonal antibody (mAb) treatment attenuates leukocyte infiltration, improves motor and autonomic function, and reduces neuropathic pain when administered at 2 hours and 24 hours after SCI. ⋯ Although delayed treatment reduced intraspinal inflammation and pain, motor function was not improved, revealing decreased efficacy at the more clinically feasibly treatment onset. Long-term anti-alpha4 mAb treatment starting 2 hours after SCI improved neurological outcomes, with tissue sparing near the lesion and no impairment of the late immune response to injury. These findings reveal no disadvantage of long-lasting immunosuppression by the treatment but show that efficacy depends upon very early delivery.
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The authors used a rat model to assess spinal cord compression following an incomplete spinal cord injury (SCI). ⋯ The authors' results suggest that spinal cord compression after the initial injury is an additional mechanism by which SCI worsens, and that the mechanism of this injury occurs rapidly. These data, however, do not support duration of compression as a significant variable.