PLoS medicine
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The prevalence of cardiovascular disease (CVD) has been increasing in children, adolescents, and young adults in recent decades. Exposure to adverse intrauterine environment in fetal life may contribute to the elevated risk of early-onset CVD. Many studies have shown that maternal hypertensive disorders of pregnancy (HDP) are associated with increased risks of congenital heart disease, high blood pressure, increased BMI, and systemic vascular dysfunction in offspring. However, empirical evidence on the association between prenatal exposure to maternal HDP and early-onset CVD in childhood and adolescence remains limited. ⋯ Offspring born to mothers with HDP, especially mothers with CVD or diabetes history, were at increased risks of overall and certain type-specific early-onset CVDs in their first decades of life. Further research is warranted to better understand the mechanisms underlying the relationship between maternal HDP and early-onset CVD in offspring.
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Comment
Tuberculosis preventive treatment in people living with HIV-Is the glass half empty or half full?
Olivia Oxlade and co-authors introduce a Collection on tuberculosis preventive therapy in people with HIV infection.
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[This corrects the article DOI: 10.1371/journal.pmed.1003323.].
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[This corrects the article DOI: 10.1371/journal.pmed.1003487.].
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Social innovations in health are inclusive solutions to address the healthcare delivery gap that meet the needs of end users through a multi-stakeholder, community-engaged process. While social innovations for health have shown promise in closing the healthcare delivery gap, more research is needed to evaluate, scale up, and sustain social innovation. Research checklists can standardize and improve reporting of research findings, promote transparency, and increase replicability of study results and findings. ⋯ The SIFHR Checklist will strengthen the reporting of social innovation for health research studies. More research is needed on social innovation for health.