PLoS medicine
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Cholera is an ancient disease that continues to cause epidemic and pandemic disease despite ongoing efforts to limit its spread. Mathematical models provide one means of assessing the utility of various proposed interventions. However, cholera models that have been developed to date have had limitations, suggesting that there are basic elements of cholera transmission that we still do not understand. ⋯ To have maximal impact on limiting epidemic spread of cholera, interventions should be targeted toward minimizing risk of transmission of the short-lived, hyperinfectious form of toxigenic Vibrio cholerae. The possibility of comparable hyperinfectious states in other major epidemic diseases also needs to be evaluated and, as appropriate, incorporated into models of disease prevention.
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Hoff and Bretthauer discuss the scientific and political controversies surrounding the introduction of a national screening programme for colorectal cancer.
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Braithwaite and Tsevat discuss a new study that suggests that antiretroviral treatment is indeed cost-effective.