PLoS medicine
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Editorial Comment
A new era of hope for the world's most neglected diseases.
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Comparative Study
Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer.
While lymph node metastasis is among the strongest predictors of disease-free and overall survival for patients with breast cancer, the immunological nature of tumor-draining lymph nodes is often ignored, and may provide additional prognostic information on clinical outcome. ⋯ These findings demonstrate that the immune profile of tumor-draining lymph nodes is of novel biologic and clinical importance for patients with early stage breast cancer.
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A common feature of research investigating the placebo effect is deception of research participants about the nature of the research. Miller and colleagues examine the ethical issues surrounding such deception.
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The dramatic protests that shut down trials of tenofovir as pre-exposure prophylaxis against HIV may prove damaging in our fight against the HIV pandemic.
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Smith explores the implications of a recent report from Britain's House of Commons Health Committee that examined the pharmaceutical industry's influence upon medicine.