Clinics
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The protocols for glucocorticoid replacement in children with salt wasting 21-hydroxylase deficiency are well established; however, the current recommendation for mineralocorticoid replacement is general and suggests individualized dose adjustments. This study aims to retrospectively review the 9-α-fludrocortisone dose regimen in salt wasting 21-hydroxylase deficient children who have been adequately treated during infancy. ⋯ The mineralocorticoid needs of salt wasting 21-hydroxylase deficient patients are greater during early infancy and progressively decrease during the first two years of life, which confirms that a partial aldosterone resistance exists during this time. Our study proposes a safety regiment for mineralocorticoid replacement during this critical developmental period.
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To assess the effect of passive body heating on the sleep patterns of patients with fibromyalgia. ⋯ Passive body heating had a positive effect on the sleep patterns of women with fibromyalgia.
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To determine the relationship between enteral nutrition discontinuation and outcome in general critically ill patients. ⋯ The determination of the difference between prescribed and received enteral nutrition seemed to be a useful prognostic marker and is feasible to be incorporated into a gastrointestinal failure score.
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Observational Study
Infection as an independent risk factor for mortality in the surgical intensive care unit.
Medical and surgical intensive care unit patients represent two different populations and require different treatment approaches. The aim of this study was to investigate the parameters associated with mortality in medical and surgical intensive care units. ⋯ Although the presence of infection is associated with a high mortality in both the medical and surgical intensive care units, the results of this prospective study suggest that infection has a greater impact in patients admitted to the surgical intensive care unit. Measures and trials to prevent and treat sepsis may be most effective in the surgical intensive care unit population.
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Comparative Study
Effects of terlipressin and naloxone compared with epinephrine in a rat model of asphyxia-induced cardiac arrest.
To evaluate the hemodynamic and metabolic effects of terlipressin and naloxone in cardiac arrest. ⋯ In this rat model of asphyxia-induced cardiac arrest, terlipressin and naloxone were effective vasopressors in cardiopulmonary resuscitation and presented better metabolic profiles than epinephrine. Terlipressin provided better hemodynamic stability than epinephrine.