Equine veterinary journal
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Equine veterinary journal · Nov 2008
Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, following intravenous administration in horses.
Current therapy protocols to treat persistent post mating endometritis and retained fetal membranes in mares typically include the administration of ecbolic drugs. Evaluation of the pharmacokinetics and tolerability of carbetocin, a long-acting oxytocin analogue, after i.v. administration is required. ⋯ Carbetocin is an attractive alternative to oxytocin therapy in broodmare management.
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Equine veterinary journal · Sep 2008
Randomized Controlled TrialEffects of a MAPK p38 inhibitor on lung function and airway inflammation in equine recurrent airway obstruction.
It has been suggested that many of the beneficial effects of corticosteroids are mediated through mitogen-activated protein kinase (MAPK) p38 inhibition. ⋯ Inhibitors of p38 MAPK with a better toxicity profile may be effective in the prevention or treatment of RAO.
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Equine veterinary journal · Jun 2008
Randomized Controlled TrialAttenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.
Absorption of endotoxin across ischaemic-injured mucosa is a major cause of mortality after colic surgery. Recent studies have shown that flunixin meglumine retards mucosal repair. Systemic lidocaine has been used to treat post operative ileus, but it also has novel anti-inflammatory effects that could improve mucosal recovery after ischaemic injury. ⋯ Treatment with systemic lidocaine ameliorated the inhibitory effects of flunixin meglumine on recovery of the mucosal barrier from ischaemic injury, when the 2 treatments were combined. The mechanism of lidocaine in improving mucosal repair has not yet been elucidated.
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Equine veterinary journal · Mar 2008
Ultrasound-guided periarticular injections of the sacroiliac region in horses: a cadaveric study.
The traditional techniques for injection of the sacroiliac (SI) region are based on external landmarks. Because of the depth of the SI joint and pathological modifications, SI injections are sometimes challenging in horses. ⋯ Each approach has advantages/drawbacks that could be favoured for selected purposes, but additional work is required to evaluate them on clinical cases.
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Equine veterinary journal · Jan 2008
Comparative StudyPlasma aldosterone, vasopressin and atrial natriuretic peptide in hypovolaemia: a preliminary comparative study of neonatal and mature horses.
Neonatal foals succumb rapidly to hypovolaemic shock in comparison to mature horses; they do not consistently increase their heart rate in response to hypotension and respond differently to fluid administration. The hormonal responses to hypovolaemia in the horse and foal require investigation. ⋯ The differences in the hormonal responses to hypovolaemia and fluid resuscitation may be important when considering fluid resuscitation of hypovolaemic horses and foals, and warrants further investigation.