Internal and emergency medicine
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Information on extracerebral system dysfunction is important for assessing the needs of critically ill patients after cardiac arrest. ⋯ Multiorgan failure is common after ROSC (1-4). Therefore, the management of patients after ROSC may require advanced multidisciplinary care. Scores describing the severity of critical illness should be routinely reported in resuscitation research. Our unique setting where withdrawal of care is illegal, allows assessment of extremely ill patients and may assist in defining margins for futility.
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Quantitative bibliometric indicators are widely used and widely misused for research assessments. Some metrics have acquired major importance in shaping and rewarding the careers of millions of scientists. Given their perceived prestige, they may be widely gamed in the current "publish or perish" or "get cited or perish" environment. ⋯ For all of those gaming practices, quantitative metrics and analyses may be able to help in their detection and in placing them into perspective. A portfolio of quantitative metrics may also include indicators of best research practices (e.g., data sharing, code sharing, protocol registration, and replications) and poor research practices (e.g., signs of image manipulation). Rigorous, reproducible, transparent quantitative metrics that also inform about gaming may strengthen the legacy and practices of quantitative appraisals of scientific work.
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Randomized Controlled Trial
Development and validation of prognostic nomogram for cirrhotic patients with acute kidney injury upon ICU admission.
This study aims to develop and validate a prognostic nomogram that accurately predicts the short-term survival rate of cirrhotic patients with acute kidney damage (AKI) upon ICU admission. For this purpose, we examined the admission data of 3060 cirrhosis patients with AKI from 2008 to 2019 in the MIMIC-IV database. All included patients were randomly assigned to derivation and validation cohorts in a 7:3 ratio. ⋯ The model's calibration plot demonstrated high consistency between predicted and actual probabilities. Furthermore, the DCA showed that the nomogram was clinically valuable. Therefore, the developed and internally validated prognostic nomogram exhibited favorable discrimination, calibration, and clinical utility in forecasting the 15-day and 30-day survival rates of cirrhosis patients with AKI upon admission to the ICU.
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Observational Study
Emergency department crowding increases 10-day mortality for non-critical patients: a retrospective observational study.
The current evidence suggests that higher levels of crowding in the Emergency Department (ED) have a negative impact on patient outcomes, including mortality. However, only limited data are available about the association between crowding and mortality, especially for patients discharged from the ED. The primary objective of this study was to establish the association between ED crowding and overall 10-day mortality for non-critical patients. ⋯ A more precise, mortality-associated threshold of crowding was identified at EDOR 0.9. The subgroup analysis did not yield any statistically significant findings. The risk for 10-day mortality increased among non-critical ED patients treated during the highest EDOR quartile.