International journal of chronic obstructive pulmonary disease
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Int J Chron Obstruct Pulmon Dis · Jan 2015
A bibliometric analysis of the 100 most influential papers on COPD.
We aimed to identify the 100 top-cited articles published on chronic obstructive pulmonary disease (COPD) and to analyze their characteristics so as to provide information on the achievement and development in COPD research over the past decades. ⋯ Our bibliometric analysis provides a historical perspective on the progress of scientific research on COPD. Articles originating from the United States and published in high-impact specialized respiratory journals are most likely to be cited in the field of COPD research.
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Int J Chron Obstruct Pulmon Dis · Jan 2015
Comprehensive analysis of gene-expression profile in chronic obstructive pulmonary disease.
To investigate the gene-expression profile of chronic obstructive pulmonary disease (COPD) patients and explore the possible therapeutic targets. ⋯ Our results may help further the understanding of the mechanisms of COPD. The identified DEGs, especially HLA-A, may serve as diagnosis markers for COPD.
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Int J Chron Obstruct Pulmon Dis · Jan 2015
Observational StudyPersonalized pulmonary rehabilitation and occupational therapy based on cardiopulmonary exercise testing for patients with advanced chronic obstructive pulmonary disease.
Personalized pulmonary rehabilitation including occupational therapy improves the prognosis of patients with advanced COPD. ⋯ The PPR-OT program improved the survival of patients with advanced COPD probably because it modified life-threatening conditions.
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Int J Chron Obstruct Pulmon Dis · Jan 2015
The inspiratory capacity/total lung capacity ratio as a predictor of survival in an emphysematous phenotype of chronic obstructive pulmonary disease.
Forced expiratory volume in 1 second (FEV1) grades severity of COPD and predicts survival. We hypothesize that the inspiratory capacity/total lung capacity (IC/TLC) ratio, a sensitive measure of static lung hyperinflation, may have a significant association with survival in an emphysematous phenotype of COPD. ⋯ Adjusting for age and sex, IC/TLC ≤25% is related to increased risk of death, and IC/TLC as a continuum, is a significant predictor of mortality in emphysematous COPD patients.
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Int J Chron Obstruct Pulmon Dis · Jan 2015
Does eosinophilic COPD exacerbation have a better patient outcome than non-eosinophilic in the intensive care unit?
COPD exacerbations requiring intensive care unit (ICU) admission have a major impact on morbidity and mortality. Only 10%-25% of COPD exacerbations are eosinophilic. ⋯ COPD exacerbations with acute respiratory failure requiring ICU admission had a better outcome with a peripheral eosinophil level >2%. NLR and peripheral eosinophilia may be helpful indicators for steroid and antibiotic management.