Neonatology
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Pulmonary hypertension and secondary cardiac dysfunction are important contributors of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Milrinone, a phosphodiesterase-3 inhibitor, may be useful in this setting for its combined actions as a pulmonary vasodilator and to improve systolic and diastolic function. ⋯ Milrinone use was associated with an improvement in systolic and diastolic function in the RV, corresponding to an improvement in clinical status.