Bulletin of the NYU hospital for joint diseases
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In a follow-up study, patients are monitored over time. Longitudinal and time-to-event studies are the two most important types of a follow-up study. In this paper, the focus is on longitudinal studies with a continuous response where patients are examined at several time points. ⋯ We will illustrate that there are interpretational and computational issues with the "classical" approaches. Further, we expand here on more appropriate statistical techniques to analyze longitudinal studies. To this end, we focus on randomized controlled trials (RCTs) and illustrate the approaches on data from a fictive randomized controlled trial in rheumatology.
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Bull NYU Hosp Jt Dis · Jan 2012
ReviewCorticosteroids as disease modifying drugs in rheumatoid arthritis treatment.
The current approach to treatment of RA includes early and aggressive treatment with routine monitoring of outcomes to give patients the best chance of decreasing disease activity as much as possible, with low disease activity and remission being a realistic goal for many patients. In this quest, DMARDs, especially MTX, are the anchor treatment, and low dose prednisone should also be considered in combination with MTX as the best initial choice for RA treatment. Current data suggest that corticosteroids are disease modifying agents that enhance the effects of DMARDs with no real impact on adverse events. We are much better positioned now then in earlier times to provide a good outcome for our patients, and every available tool needs to be considered and utilized for this purpose.
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Bull NYU Hosp Jt Dis · Jan 2012
Case ReportsExtensor indicis proprius and extensor digitorum communis rupture after volar locked plating of the distal radius--a case report.
Distal radius fractures are among the most commonly encountered fractures in the extremities. Volar plating of distal radius fracture has gained popularity in recent years with the introduction of the locked plating system. Complications of volar plating include extensor and flexor tendon rupture. Here we present a case report of an extensor indicis proprius and extensor digitorum communis to index finger tendon rupture after open reduction and internal fixation of distal radius fracture with locked plate.