Medicina
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Klebsiella pneumoniae liver abscess syndrome due to hypermucoviscous strains is defined by the presence of monomicrobial liver abscess, without biliary tree or colorectal disease. These strains may be easily identified in the laboratory by performing a string test. It has the potential to spread to other organs, leading to a high morbimortality. We report two cases of liver abscess due to naturally susceptible Klebsiella pneumoniae, one of them with endogenous endophthalmitis as metastatic involvement that required evisceration.
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Malignant rhabdoid tumor (MRT) is a highly aggressive disease, mainly affecting infants and small children. ⋯ Although the sample size is small, survival rates are similar or slightly lower than other series. Age was the main prognostic factor. All but one patient that received MT are alive, suggesting that MT might have a role in ERNC-MRT; however, the prognostic significance is not entirely clear since there are multiple confounding factors.
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The prevalence of polycystic ovary syndrome (PCOS) in transgender and non-binary genders assigned female at birth (TMNBG) men is controversial. Our objectives were to investigate the prevalence, phenotypic characteristics of PCOS, and cardiometabolic risk of TMNBG with and without PCOS prior to hormone therapy. ⋯ PCOS appears to be prevalent among TMNBG. Transgender people with PCOS may exhibit an unfavorable cardiometabolic risk profile compared to those without PCOS, especially due to a higher BMI. It is necessary to evaluate the specific components of PCOS before starting hormonal therapy due to the long-term implications it could have.
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Tuberculosis (TB) in Argentina has been on the rise in recent years, with a higher notification rate in the 15 to 49-year-old age group. Although it is estimated that the incidence of TB in pregnant and postpartum individuals is higher than in the general population, there is insufficient data in our country. ⋯ We report a case of congenital TB transmission diagnosed through epidemiological criteria and molecular methods. We emphasize the importance of implementing TB screening algorithms in pregnancy, tailored to the populations served and the resources available, and we highlight the contribution of genomic sequencing at clinical and epidemiological levels.
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Congenital central alveolar hypoventilation (CCAH), previously called Ondine Syndrome, is a rare disease, with an incidence of 1/200000 births and a prevalence of 1/500000. It is a defect in the central control of ventilation, not explained by muscular, neurological, cardiological, or pulmonary abnormalities. Early diagnosis is important to avoid episodes of hypoxia and hypercapnia, which overshadow the prognosis. ⋯ Two members of the same family are presented, mother and daughter with different clinical presentations. CCAH is a diagnostic challenge. Suspected or confirmed cases should be evaluated in reference centers.