The American journal of cardiology
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Acute chest pain (CP), a leading symptom of persons presenting to emergency departments (EDs), may represent a life-threatening emergency or nonurgent condition requiring routine outpatient follow-up. In either case, rapid provision of an electrocardiogram and clinician evaluation are essential for determining appropriate treatment or discharge from the ED. Data from the National Hospital Ambulatory Medical Care Survey were used to estimate the proportion of hospital ED visits for a chief symptom of CP in adults aged >or=25 years with documentation of both an electrocardiogram and mean and/or median wait time to see a clinician in the ED. ⋯ Median wait times for a physician were 12 minutes for those with ischemic CP, 15 minutes for those with other cardiac CP, 18 minutes for those with undifferentiated CP, and 25 minutes for those with noncardiac CP. From 1993 to 2004, ED visits for CP increased for younger (25 to 64 years) adults (1993: 15.6 per 1,000 population, 2.5 million visits vs 2004: 20.9 per 1,000, 4.0 million) and decreased for older adults (>or=65 years) (1993: 9.7 per 1,000; 1.5 million vs 2004: 7.3 per 1,000; 1.3 million). In conclusion, most ED patient visits for undifferentiated and cardiac CP included an electrocardiogram and timely clinician evaluation.
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ST-segment depression (ST-D) on the admission electrocardiogram of patients with non-ST-elevation acute coronary syndromes (NSTEACSs) is associated with higher mortality. However, few studies have evaluated the effect of location of ST-D and T-wave polarity on long-term prognosis of patients with NSTEACS. Electrocardiographic (ECG) and clinical data from 6,770 patients with NSTEACS randomly assigned in the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIB trial were analyzed retrospectively. ⋯ Logistic regression analysis showed that age, hyperlipidemia, Killip class>I, history of myocardial infarction, history of heart failure, history of angina pectoris, systolic blood pressure, heart rate, sum of ST-D (odds ratio 1.061, 95% confidence interval 1.035 to 1.087, p<0.001), and ST-D with T-wave inversion in leads V4 to V6 (odds ratio 1.374, 95% CI 1.023 to 1.844, p=0.035) were independent predictors of 1-year mortality. Conversely, ST-D without T-wave inversion in leads V4 to V6 or other ECG presentations were not independent predictors of high 1-year mortality. In conclusion, ST-D with T-wave inversion in leads V4 to V6 on the admission electrocardiogram in patients with NSTEACS identifies those with higher 1-year mortality than for patients with any other ECG presentation.
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The usefulness of 64-slice multidetector coronary computed tomography (MDCT) in a diagnostic triage of 100 consecutive patients (age 55.8+/-11.6 years; 57% men) with chest pain suspected to be ischemic in origin and a negative or nondiagnostic exercise treadmill test (ETT) result was examined. None of the patients had previously known coronary artery disease (CAD). MDCT showed obstructive (>or=50%) CAD in 29 patients; 13 of 59 patients (22%) with a negative and 16 of 41 patients (39%) with a nondiagnostic ETT result. ⋯ For the 71 patients without obstructive CAD on MDCT, clinically driven invasive angiography detected CAD in 1 of 15 patients (1 false-negative MDCT result) and 2 of another 5 patients who were referred for invasive angiography later during a 12-month follow-up period. In the remaining 51 patients, MDCT findings effectively allowed exclusion of obstructive CAD, and there were no major adverse clinical events during follow-up. In conclusion, in patients with chest pain possibly ischemic in origin, no previously known CAD, and a negative or nondiagnostic ETT result, contrast-enhanced 64-slice MDCT scanning was a useful tool to provide direct noninvasive coronary angiography and rapidly advance diagnostic triage.