Anaesthesiology intensive therapy
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Anaesthesiol Intensive Ther · Oct 2012
ReviewAssessment of three minimally invasive continuous cardiac output measurement methods in critically ill patients and a review of the literature.
In this study we compared the accuracy of three continuous cardiac output (CCO) measurement methods, with intermittent transcardiopulmonary thermodilution (TPTD-CO) as the gold standard. The three studied CCO measurement methods were: uncalibrated peripheral pulse contour measurement (FCCO), calibrated central pulse contour measurement (PCCO), and CCO obtained by indirect Fick principle (NCCO). ⋯ These results indicate that in our patient population, CCO can be most reliably monitored by calibrated central pulse contour measurements. All other methods appeared less accurate, especially in situations of low SVRI.
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Anaesthesiol Intensive Ther · Jul 2012
ReviewPharmacokinetic-pharmacodynamic modelling of antibiotic therapy in severe sepsis.
The antibiotic treatment of severe sepsis poses an increasing challenge in ICU. The multidrug resistance and diverse pharmacokinetics of antibiotics requires a different approach on antibiotic therapy because of the inadequate serum antibiotic levels found in ICU patients. The current guidelines or recommendations of antibiotic treatment take into account the pharmacokinetic parameters in determining the proper dosage. The recommended antibiotic treatment of severe sepsis requires daily assessment and dosage adjustment based on measurements of antibiotic concentrations in order to optimize the treatment.
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Anaesthesiol Intensive Ther · Jul 2012
Comparative StudyComparison of target controlled infusion and total intravenous anaesthesia with propofol and remifentanil for lumbar microdiscectomy.
Propofol is often combined with remifentanil for induction and maintenance of total intravenous anaesthesia. Target-controlled infusion (TCI) permits adapting infusion to pharmacokinetic models. In this study we compared depth of anaesthesia, haemodynamic variables and times to recovery in patients scheduled for lumbar microdiscectomy and receiving either manually controlled (group I) or target- controlled (group II) infusion of propofol and remifentanil for anaesthesia. ⋯ There are no clinically important differences in haemodynamic variables, depth of anaesthesia, time to recovery and doses of propofol/remifentanil between manually controlled and target-controlled infusion of propofol and remifentanil.