Journal of aerosol medicine and pulmonary drug delivery
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J Aerosol Med Pulm Drug Deliv · Jun 2015
Multicenter StudyInhaler devices for chronic obstructive pulmonary disease: insights from patients and healthcare practitioners.
The choice of inhaler device for patients with chronic obstructive pulmonary disease (COPD) depends upon multiple attributes. An online survey was devised to assess COPD patients' and healthcare practitioners' (HCPs; physicians and nurses) opinions and preferences for inhaler devices. ⋯ The survey provides important insights into what patients and HCPs consider to be key attributes of an ideal inhaler device for COPD management. Given that patients with COPD self-administer their COPD chronic medication and need to deliver the correct dose, it is important to consider these insights for the appropriate management of COPD.
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J Aerosol Med Pulm Drug Deliv · Jun 2015
Efficient Nose-to-Lung (N2L) Aerosol Delivery with a Dry Powder Inhaler.
Delivering aerosols to the lungs through the nasal route has a number of advantages, but its use has been limited by high depositional loss in the extrathoracic airways. The objective of this study was to evaluate the nose-to-lung (N2L) delivery of excipient enhanced growth (EEG) formulation aerosols generated with a new inline dry powder inhaler (DPI). The device was also adapted to enable aerosol delivery to a patient simultaneously receiving respiratory support from high flow nasal cannula (HFNC) therapy. ⋯ The developed DPI produced high efficiency aerosolization with significant size increase of the aerosol within the airways that can be used to enable nose-to-lung delivery and aerosol administration during HFNC therapy.
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J Aerosol Med Pulm Drug Deliv · Jun 2015
Indacaterol determination in human urine: validation of a liquid-liquid extraction and liquid chromatography-tandem mass spectrometry analytical method.
Indacaterol is a novel once-a-day inhaled ultra-long-acting β2-agonist. Quantitative bioanalysis supports pharmacokinetic and clinical research. The aim of the current work was to validate an in-house developed high performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS) analytical method for indacaterol determination in human urine samples. ⋯ A specific, accurate and precise HPLC-MS/MS method has been validated for indacaterol quantification in human urine. This simple method is reproducible and robust to support future, indacaterol-related pharmacokinetic, bioequivalence and clinical studies.
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J Aerosol Med Pulm Drug Deliv · Apr 2015
Randomized Controlled TrialThe effect of beclometasone dipropionate/formoterol extra-fine fixed combination on the peripheral airway inflammation in controlled asthma.
Suppression of small airway inflammation may contribute to achieving asthma control. We aimed to evaluate the additional effect of beclometasone dipropionate/formoterol (BDP/F) hydrofluoroalkane (HFA) pressurized metered dose inhaler (pMDI) (BDP/F-HFA 100/6 μg pMDI) on airway inflammation and functional parameters in asthma cases, who were optimally controlled by maintenance therapy. ⋯ These results emphasize that asthma treatment has mainly focused on the strategy to keep the disease under control; maintaining optimal functional level might be underestimated. BDP/F-HFA may have an additional favorable effect on the peripheral airway inflammation in the controlled asthma.
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J Aerosol Med Pulm Drug Deliv · Feb 2015
Comparative StudyMeasurements of droplet size distribution and analysis of nasal spray atomization from different actuation pressure.
To evaluate the deposition efficiency of spray droplets in a nasal cavity produced from a spray device, it is important to determine droplet size distribution, velocity, and its dispersion during atomization. Due to the limiting geometric dimensions of the nasal cavity airway, the spray plume cannot develop to its full size inside the nasal vestibule to penetrate the nasal valve region for effective drug deposition. ⋯ The experimental technique presented is able to capture a more complete representation of the droplet size distribution and the atomization process during an actuation. The measured droplet size distribution produced can be related to the empirically defined deposition efficiency curve of the nasal cavity, allowing a prediction of the likely deposition.