Oxidative medicine and cellular longevity
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Oxid Med Cell Longev · Jan 2015
Dexmedetomidine attenuates oxidative stress induced lung alveolar epithelial cell apoptosis in vitro.
Oxidative stress plays a pivotal role in the lung injuries of critical ill patients. This study investigates the protection conferred by α 2 adrenoceptor agonist dexmedetomidine (Dex) from lung alveolar epithelial cell injury induced by hydrogen peroxide (H2O2) and the underlying mechanisms. ⋯ Our study demonstrated that Dex protected lung alveolar epithelial cells from apoptotic injury, cell cycle arrest, and loss of cell adhesion induced by H2O2 through enhancing the cell survival and proliferation.
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Oxid Med Cell Longev · Jan 2015
Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator.
To evaluate the role of SIRT1 in small intestine damage following severe hemorrhagic shock and to investigate whether polydatin (PD) can activate SIRT1 in shock treatment. ⋯ The results collectively suggest a role for the SIRT1-PGC-1α-SOD2 axis in small intestine injury following severe hemorrhagic shock and that PD is an effective SIRT1 activator for the shock treatment.