No to hattatsu. Brain and development
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Duchenne muscular dystrophy is the most common inherited muscular disease, characterized by progressive muscle wasting, commonly leading to death in the twenties due to cardiac or respiratory failure. In order to establish treatment for Duchenne muscular dystrophy, many kinds of studies including gene transfer strategies have been conducted, but no effective treatment has been established. ⋯ The other one is the induction of read-through of nonsense mutation which ignores a premature stop codon to translate dystrophin mRNA into dystrophin. Here, these two ways are presented and discussed.
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Here we report a 12-year-old boy with idiopathic neuralgic amyotrophy who had two episodes of shoulder pain followed by shoulder muscle atrophy and weakness at the age of 7 and 11 years, respectively. These symptoms were self-limited and disappeared within 9 months. During the second episode, electromyograph (EMG) revealed neurogenic changes in the deltoid muscle. ⋯ Neuralgic amyotrophy is characterized by neuralgic pain followed by weakness and atrophy at a unilateral extremity and is usually self-limited. EMG and imaging studies showed focal neurogenic abnormalities, which were confirmed by muscle biopsy. Neuralgic amyotrophy usually occurs in young adults and it is very rare in children.