Arthritis care & research
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Arthritis care & research · Sep 2011
Randomized Controlled TrialPredicting response to a cognitive-behavioral approach to treating low back pain: Secondary analysis of the BeST data set.
Identifying factors that predict who is likely to gain the greatest benefit from different treatments for low back pain is an important research priority. Here we report moderator analyses of the Back Skills Training Trial (BeST) that tested a cognitive-behavioral approach for low back pain. ⋯ Although BeST is one of the larger trials of back pain treatment, it is still too small to reliably detect moderation if it exists. Since the significant moderation effects were only observed for 1 outcome measure in 3 of 10 post-hoc analyses, we cannot conclude that these are true moderation effects.
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Arthritis care & research · Aug 2011
Randomized Controlled Trial Multicenter StudyPhase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate.
To compare the efficacy, safety, and tolerability of 4 doses of oral tofacitinib (CP-690,550) with placebo in Japanese patients with active rheumatoid arthritis (RA) receiving stable background methotrexate (MTX) who had an inadequate response to MTX alone. ⋯ In Japanese patients with active RA with an inadequate response to MTX, tofacitinib in combination with MTX over 12 weeks was efficacious and had a manageable safety profile.
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Arthritis care & research · Jul 2011
Importance of self-rated health and mental well-being in predicting health outcomes following total joint replacement surgery for osteoarthritis.
The determinants of outcomes and the scope of outcomes examined in total joint replacement (TJR) typically have been limited to aspects of physical health. We investigated mental well-being, physical and social health, and self-rated health (SRH) as predictors of future health status within a cohort undergoing a TJR for hip or knee osteoarthritis. We also investigated the interrelationships among these health dimensions as they relate to SRH. ⋯ Mental well-being is critical for understanding the relationship between physical health and SRH. In addition, SRH significantly predicts TJR outcomes, above and beyond prior physical health. The exclusive focus on any one health dimension may lead to missed opportunities for predicting and improving outcomes following surgery, and likely improving overall health generally.
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Arthritis care & research · Jul 2011
Access to pediatric subspecialty care: a population study of pediatric rheumatology inpatients in California.
To examine trends in the specialty care hospitalization of pediatric rheumatology patients and determine how nonclinical factors influence access. ⋯ Nonclinical factors play an increasingly important role in the hospitalization patterns of pediatric rheumatology patients in California. Understanding these factors is crucial if we are to ensure that the variation in access to care reflects clinical need.
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Arthritis care & research · Jul 2011
Ultrasound findings on patients with juvenile idiopathic arthritis in clinical remission.
To assess whether children with juvenile idiopathic arthritis (JIA) in clinical remission show pathologic findings on either gray-scale or power Doppler ultrasound of their joints. ⋯ This study demonstrates that some patients who meet clinical criteria for remission continue to show ongoing pathology on joint ultrasound, which may be suggestive of persistent inflammation.