Injury
-
Proinflammatory cytokines released from nerve endings and surrounding injured tissue after nerve damage can prolong the inflammation process, delay nerve healing or result in poor quality nerve healing. In this case, due to the loss of function in the muscles innervated by the damaged nerve, the patient may have neurological and functional difficulties which may reduce the patient's quality of life and create an economic burden. Although the attempts of many pharmacological agents to heal crush injury of peripheral nerves have been recorded in literature, a drug that can provide adequate recovery of the crushed nerve and can be applied in daily life has not been defined as yet. This study aimed to assess the effects of calcium dobesilate on sciatic nerve crush injury in a rat model. ⋯ The study results demonstrated that calcium dobesilate could suppress inflammatory processes and provide histopathological and functional improvements in the injured nerve in rats. Therefore, further clinical studies are recommended to investigate in detail the therapeutic effects of calcium dobesilate on peripheral nerve crush injury.
-
Firearm-related injuries impact the healthcare system, taxpayers, and injured patients due to lost productivity and reduced quality of life. The goal was to quantify the economic costs related to hospitalization for gunshot wounds (GSWs) at a single urban level 1 trauma center. ⋯ Level III.
-
To guide iliosacral screws (ISS) and verify safe placement different techniques, e.g. Fluoroscopy-guided (FSG) or 3D navigation are known. However, higher radiation exposure for the conventional technique is a concern. It was the aim of this experimental study to evaluate radiation exposure for three clinical workflows. ⋯ Intraoperative 3D scanning may be recommended, either combined with prior FSG ISS placement or following 3D navigation without increasing radiation exposure compared with alternative workflows with postoperative CT control.