Chest
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Randomized Controlled Trial Multicenter Study
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock.
We sought to compare the association of whole-blood lactate kinetics with survival in patients with septic shock undergoing early quantitative resuscitation. ⋯ In patients in the ED with a sepsis diagnosis, early lactate normalization during the first 6 h of resuscitation was the strongest independent predictor of survival and was superior to other measures of lactate kinetics.