Chest
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Randomized Controlled Trial Comparative Study Clinical Trial
Response to add-on inhaled corticosteroids in COPD based on airway hyperresponsiveness to mannitol.
The use of inhaled corticosteroids in mild to moderate COPD is controversial. The aim of this study was to determine whether airway hyperresponsiveness to mannitol might identify patients who are likely to respond to add-on inhaled corticosteroids. ⋯ In subjects with mild to moderate COPD and airway hyperresponsiveness to mannitol, quality of life and airway responsiveness improved after treatment with inhaled corticosteroids added to long-acting bronchodilator therapy.
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Randomized Controlled Trial Comparative Study Clinical Trial
Complete unilateral vs partial bilateral endoscopic lung volume reduction in patients with bilateral lung emphysema.
Intrabronchial valve placement for endoscopic lung volume reduction is used for patients with severe lung emphysema. Different treatment approaches are unilateral valve placement with the goal of complete occlusion and subsequent atelectasis leading to true volume reduction vs bilateral partial closure aiming for redistribution of ventilation but avoiding atelectasis. In this prospective pilot trial, we compared the efficacy of these treatment approaches. ⋯ Unilateral intrabronchial valve placement with complete occlusion appears superior to bilateral partial occlusion.