Medizinische Klinik, Intensivmedizin und Notfallmedizin
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Med Klin Intensivmed Notfmed · Apr 2014
Review[Pharmacokinetic and pharmacodynamic aspects in antibiotic treatment].
Severe sepsis and septic shock have a high mortality and, therefore require fast and effective antibiotic treatment with low toxicity. Because of sepsis-induced pathophysiological changes, pharmacokinetics of antimicrobial agents can be altered. Particularly water-soluble drugs display an enhanced volume of distribution during early sepsis. ⋯ They can result in severe complications such as renal failure or ventricular arrhythmias. Conversely, enzyme induction may lead to subtherapeutic drug levels. When continuous renal replacement therapy is required, the dosage of antibiotics has to be adapted according to the results of respective pharmacokinetic studies.
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Med Klin Intensivmed Notfmed · Apr 2014
[The respiratory therapist in the intensive care unit team].
Qualified respiratory therapists have been an integral part of the U. S. health care system for over 50 years now and are an indispensable part of the system. ⋯ Since 2005, the German Respiratory Society also offers nurses and physiotherapists training in respiratory therapy. The core competencies of the numerous intensive care respiratory therapists employed in German intensive care units include, among others, the diagnosis and treatment of acute and chronic respiratory failure, including invasive and non-invasive respiratory therapy, excessive secretion management, including bronchoscopic airway clearance, and inhalation therapy.