Stroke; a journal of cerebral circulation
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Clinical Trial
Incident hemorrhage risk of brain arteriovenous malformations located in the arterial borderzones.
We sought to assess the relative risk of hemorrhagic presentation of brain arteriovenous malformations (AVMs) located in the arterial borderzone territories. ⋯ Our findings suggest that borderzone location is an independent determinant for a lower risk of AVM hemorrhage at initial presentation.
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We sought to identify the most powerful binary measures of the treatment effect of tissue plasminogen activator (tPA) in the National Institute of Neurological Disorders and Stroke (NINDS) rTPA Stroke Trial. ⋯ Measures using the NIHSS and a Rankin score =1 were the most sensitive discriminators of the effectiveness of tPA in the NINDS tPA Stroke Trial compared with the other clinical and radiological measures. The outcome measures identified in this exploratory analysis (eg, NIHSS score =2 at 24 hours) would be best used as an outcome measure in future phase II trials of recanalization begun within the first 3 hours after stroke onset, with inclusion and exclusion criteria similar to those in the NINDS tPA Stroke Trial.