Stroke; a journal of cerebral circulation
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Comparative Study
Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage.
Studies indicate that thrombin plays an important role in intracerebral hemorrhage (ICH)-induced edema formation. Although thrombin is produced as the blood clots, it may be bound to fibrin and only gradually released from the clot. The time window for administration of a thrombin inhibitor to reduce ICH-induced edema is unknown. Whether this time window extends beyond the period when a thrombin inhibitor might exacerbate rebleeding is also unknown. ⋯ Our data suggest that argatroban may be an effective therapy for ICH-induced edema.