JAMA internal medicine
-
JAMA internal medicine · Feb 2017
Association of Perioperative Statin Use With Mortality and Morbidity After Major Noncardiac Surgery.
The efficacy of statins in reducing perioperative cardiovascular and other organ system complications in patients undergoing noncardiac surgery remains controversial. Owing to a paucity of randomized clinical trials, analyses of large databases may facilitate informed hypothesis generation and more efficient trial design. ⋯ Early perioperative exposure to a statin was associated with a significant reduction in all-cause perioperative mortality and several cardiovascular and noncardiovascular complications. However, the potential for selection biases in these results must be considered.