The Mount Sinai journal of medicine, New York
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Randomized Controlled Trial Clinical Trial
Preemptive epidural analgesia for thoracic surgery.
The purpose of this study was to determine if preemptive epidural analgesia performed before thoracotomy incision and during the operation reduces postoperative pain. Patients in the treatment group received 8 mL of 0.25% bupivacaine and 2 mL of fentanyl (50 microg/mL) via the epidural route prior to skin incision, followed by an infusion of bupivacaine 0.1% and fentanyl 10 microg/mL at 6 mL/hr. ⋯ The patients in the treatment group required less isoflurane intraoperatively and had lower maximum pain scores in the first 6 hours postoperatively. No significant differences were noted after the first 6 hours.
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Endovascular aortic repair is a new alternative to conventional surgical techniques. A variety of devices available for endovascular aortic repair are discussed and the outcomes after repair are reviewed. Anesthetic considerations during endovascular repair are dictated by the device being used, as well as the site of device deployment. ⋯ Patients undergoing repair of thoracic aortic pathology may be candidates for perioperative transesophageal echocardiographic monitoring. Since a subgroup of these patients may be at risk for postoperative paraplegia, aggressive spinal cord protection should be considered. Patients with large aneurysms may be at risk for "post-implantation syndrome," which is characterized by hyperpyrexia, hypotension, and coagulopathy.
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There has been growing interest in defining and measuring outcomes for cardiac surgical patients. Outcomes measures have been used in many hospitals as tools for measuring the quality of care, although it is difficult to infer from them how care might be improved. Traditionally, the major outcome endpoints used in cardiac surgery have been the 30-day mortality and morbidity rates. ⋯ By using outcome prediction tools and making conclusions based on preoperative risk factor information, surgeons and anesthesiologists are able to make better decisions about treatment strategies. Additionally, operating room and intensive care unit personnel can use these data to schedule cases and allocate resources more efficiently. These data are also very important for hospital administrators and insurance providers.
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Review
The open lung concept of alveolar recruitment can improve outcome in respiratory failure and ARDS.
Respiratory failure is a common finding in the ICU and in the management of complex cases in the operating room. Over the last ten years, it has become clear that modes of mechanical ventilation and lung recruitment may play a role both in cytokine modulation and patient outcome. Early lung recruitment and alveolar stabilization may play a very important role in the management of patients with respiratory failure and adult respiratory distress syndrome (ARDS). ⋯ This technique not only improves oxygenation, but also affects surfactant function and cytokine modulation. The open lung concept is physiologically based on the Law of Laplace. Adhering to the principles of the open lung concept, pressure-controlled ventilation may improve patient outcome by reducing the extent of irreversible structural damage to the lungs caused by mechanical ventilation.
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Comparative Study
Comparison of arterial systolic pressure variation with other clinical parameters to predict the response to fluid challenges during cardiac surgery.
Prophylactic optimization of stroke volume during surgery has been thought by some to reduce complications following surgery. Mechanical ventilation has been shown to induce variations in systolic systemic arterial blood pressure. Measuring such variations in systolic pressure (SPV) might serve as an attractive method for guiding fluid therapy intraoperatively. ⋯ Although significant intergroup differences in the extent of systolic pressure variations were observed, no appropriate threshold values could be determined that would accurately predict the response to a fluid bolus. There is a relationship between SPV and SPVdown values and intravascular volume status. SPV and echocardiographic-derived values did not predict the response to a fluid bolus as well as values obtained from the pulmonary artery catheter.