The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Oct 2013
IL-13 receptor α2 contributes to development of experimental allergic asthma.
IL-13 receptor α2 (IL-13Rα2) binds IL-13 with high affinity and modulates IL-13 responses. There are soluble and membrane forms of IL-13Rα2 generated by alternative splicing in mice, but human subjects express only the membrane form of IL-13Rα2 (memIL-13Rα2). ⋯ These data collectively support a distinct role for memIL-13Rα2 in the lung and suggest that memIL-13Rα2 might contribute to allergic inflammation.