The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Nov 2013
Anaphylaxis: clinical patterns, mediator release, and severity.
Prospective human studies of anaphylaxis and its mechanisms have been limited, with few severe cases or examining only 1 or 2 mediators. ⋯ The results suggest that multiple inflammatory pathways drive reaction severity and support recommendations for safe observation periods after initial treatment.