The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Apr 2007
Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia.
Familial cold autoinflammatory syndrome (FCAS) is characterized by rash, fever, and arthralgia in response to cold exposure. CIAS1, the gene that codes for cryopyrin, is mutated in FCAS. Treatment with anakinra (IL-1 receptor antagonist) prevents symptoms, indicating a crucial role for IL-1 in this disease. ⋯ These results confirm the central role of IL-1beta in FCAS and support the use of IL-1 targeted therapy in these patients.
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J. Allergy Clin. Immunol. · Apr 2007
Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies.
Human intravenous immunoglobulin (IVIg) preparations are used for the treatment of autoimmune and allergic diseases. Natural autoantibodies are believed to contribute to IVIg-mediated anti-inflammatory effects. ⋯ Anti-Siglec-8 autoantibodies present in IVIg preparations may have therapeutic relevance in autoimmune and allergic diseases, respectively, such as Churg-Strauss syndrome.
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J. Allergy Clin. Immunol. · Mar 2007
Severe intermittent wheezing in preschool children: a distinct phenotype.
Young children with wheezing predominantly with respiratory tract illnesses experience severe exacerbations separated by extended periods of wellness and may be described as having "severe intermittent wheezing," a diagnostic category not currently recognized in national guidelines. ⋯ Preschool children with recurrent severe wheezing episodes experience significant illness-related morbidity and exhibit features of atopic predisposition.