The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Oct 2004
Randomized Controlled Trial Multicenter Study Clinical TrialCoseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis.
We wondered whether short-term coseasonal sublingual immunotherapy (SLIT) can reduce the development of asthma in children with hay fever in an open randomized study. ⋯ Three years of coseasonal SLIT improves seasonal allergic rhinitis symptoms and reduces the development of seasonal asthma in children with hay fever.
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J. Allergy Clin. Immunol. · Oct 2004
High prevalence of autoimmune urticaria in children with chronic urticaria.
The etiology of chronic urticaria (CU) in childhood often remains unrecognized. Recently, in adults it has been shown that approximately 40% of patients with CU have autoimmune urticaria (AU); however, no data are available in children. ⋯ Our results demonstrate for the first time that children have the same ability as adults to produce functionally active autoantibodies directed against IgE or IgE receptor and that AU occurs in children in as many as 30% of cases. The addition of screening for AU dramatically decreases the rate of the idiopathic form from 52% to 20%.
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J. Allergy Clin. Immunol. · Oct 2004
Letter Case ReportsRecurrent anaphylaxis linked to pantoprazole.
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J. Allergy Clin. Immunol. · Sep 2004
Comparative Study Clinical TrialSafety and application of induced sputum analysis in childhood asthma.
The value of sputum induction in pediatric asthma lies in its potential to directly and noninvasively assess airway inflammation in children, because bronchoscopy and biopsy carry some risk. The Childhood Asthma Management Program (CAMP) study was designed to evaluate the long-term effects of budesonide and nedocromil compared with placebo in children with mild to moderate asthma across 8 centers. ⋯ Sputum induction is a relatively noninvasive and safe procedure that can provide information on eosinophilic inflammation and treatment response and is also associated with several measures of asthma control. However, this procedure still remains a research tool in asthma because of its requirements for technical expertise.