The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Feb 1998
Randomized Controlled Trial Multicenter Study Clinical TrialSalmeterol improves quality of life in patients with asthma requiring inhaled corticosteroids. Salmeterol Quality of Life Study Group.
Traditional clinical outcomes have demonstrated that salmeterol improves pulmonary function and reduces asthma symptoms. However, they do not evaluate how patients perceive the effect of therapeutic intervention on day-to-day functioning and well-being. ⋯ Salmeterol provided significantly greater improvement in quality-of-life outcomes in patients whose asthma symptoms are not well controlled with inhaled corticosteroids. These results demonstrate that the benefits of salmeterol are not limited to conventional clinical measures of efficacy.
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J. Allergy Clin. Immunol. · Feb 1998
Identification of common allergenic structures in mugwort and ragweed pollen.
Identification of common allergenic structures in mugwort and ragweed pollen. ⋯ In addition to profilin, mugwort and ragweed pollen contain a number of cross-reactive allergens, among them the major mugwort allergen Art v 1. Cross-reactive IgE antibodies can lead to clinically significant allergic reactions.
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J. Allergy Clin. Immunol. · Jan 1998
Can a threshold limit value for natural rubber latex airborne allergens be defined?
Recent studies have shown that systemic or respiratory occupational responses to latex can be induced by inhalation of latex aeroallergens. ⋯ Our results demonstrate that symptoms and presence of latex-specific IgE antibodies in subjects are significantly associated with measurable levels of latex aeroallergens. A latex aeroallergen level of 0.6 ng/m3 is a critical threshold, especially for health care workers who are sensitized to natural rubber latex.