The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jun 1979
Case ReportsPneumomediastinum as a complication of asthma in teenage and young adult patients.
The characteristics of 11 patients (age range, 13 to 31 yr) with asthma complicated by pneumomediastinum are presented. Nine of 11 patients were male. Cough and chest pain were prominent symptoms in the affected individuals. ⋯ Hamman's sign was detected in 7 patients. None of the patients required specific therapy for pneumomediastinum. The pathophysiology of pneumomediastinum was reviewed.
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J. Allergy Clin. Immunol. · May 1978
Administration of local anesthetics to patients with a history of prior adverse reaction.
The clinical histories of 71 patients evaluated for suspected local anesthetic (LA) allergy were reviewed retrospectively. The clinical histories were classified into (1) immediate generalized reactions (15%), (2) localized swelling at the injection site (25%), (3) nonspecific systemic symptoms (42%), and (4) other histories (17%). Serial dilutional intradermal skin tests were performed with mepivacaine, lidocaine, and procaine in 59 patients. ⋯ No significant reactions were observed in this group. Three patients tolerated a challenge with an LA to which they were skin test--positive. These data indicate (1) the low incidence of reactions compatible with a systemic IgE-mediated mechanism by history in patients referred for evaluation of LA allergy, (2) the lack of specific and clinically relevant information provided by dilutional skin tests, and (3) the apparent safety and usefulness of careful challenge with an alternative LA.
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J. Allergy Clin. Immunol. · Feb 1977
Randomized Controlled Trial Comparative Study Clinical TrialComparison of subcutaneous terbutaline with epinephrine in the treatment of asthma in children.
Comparison of the bronchodilator and cardiovascular effects of subcutaneous terbutaline and epinephrine in the treatment of acute asthmatic attacks in children disclosed that bronchodilation occurred with 5 min after subcutaneous injection of either drug (0.01 mg/kg, maximum 0.25 mg). Bronchodilation was maintained for 4 hr after administration of either drug. Small increases in pulse rate followed administration of terbutaline but not epinephrine. No clinically significant side effects were noted with either drug.