The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jan 2014
Parental psychological distress during pregnancy and wheezing in preschool children: the Generation R Study.
Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma. ⋯ Maternal psychological distress during pregnancy is associated with increased odds of wheezing in their children during the first 6 years of life independent of paternal psychological distress during pregnancy and maternal and paternal psychological distress after delivery. These results suggest a possible intrauterine programming effect of maternal psychological distress leading to respiratory morbidity.
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J. Allergy Clin. Immunol. · Jan 2014
A simple asthma prediction tool for preschool children with wheeze or cough.
Many preschool children have wheeze or cough, but only some have asthma later. Existing prediction tools are difficult to apply in clinical practice or exhibit methodological weaknesses. ⋯ This tool represents a simple, low-cost, and noninvasive method to predict the risk of later asthma in symptomatic preschool children, which is ready to be tested in other populations.
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J. Allergy Clin. Immunol. · Jan 2014
Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis.
There is increasing evidence of the effect of maternal vitamin D intake during pregnancy on the risk of asthma and allergic outcomes in offspring. However, studies on the relationship between cord levels of 25-hydroxyvitamin D (25[OH]D) and asthma and allergic diseases are very few. ⋯ Cord serum 25(OH)D levels were inversely associated with the risk of transient early wheezing and atopic dermatitis by the age of 5 years, but no association was found with asthma and allergic rhinitis.
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J. Allergy Clin. Immunol. · Jan 2014
Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis.
Aspirin-exacerbated respiratory disease (AERD) is recognized as a distinct asthma phenotype. It usually has a severe course accompanied by chronic hyperplastic eosinophilic sinusitis with nasal polyps, blood eosinophilia, and increased concentrations of urinary leukotriene E4 (LTE4). More insightful analysis of individual patients shows this group to be nonhomogeneous. ⋯ LCA revealed unique AERD subphenotypes, thus corroborating the heterogeneity of this population. Such discrimination might facilitate more individualized treatment in difficult-to-treat patients.
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J. Allergy Clin. Immunol. · Dec 2013
Randomized Controlled TrialBronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma.
Bronchial thermoplasty (BT) has previously been shown to improve asthma control out to 2 years in patients with severe persistent asthma. ⋯ These data demonstrate the 5-year durability of the benefits of BT with regard to both asthma control (based on maintained reduction in severe exacerbations and ED visits for respiratory symptoms) and safety. BT has become an important addition to our treatment armamentarium and should be considered for patients with severe persistent asthma who remain symptomatic despite taking inhaled corticosteroids and long-acting β₂-agonists.