The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Aug 2011
Randomized Controlled Trial Comparative StudyTiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma.
The efficacy and safety of inhaled long-acting β(2)-adrenergic agonists in asthmatic patients with the B16-Arg/Arg genotype has been questioned, and the use of antimuscarinics has been proposed as an alternative in patients whose symptoms are not controlled by inhaled corticosteroids (ICSs). ⋯ Tiotropium was more effective than placebo and as effective as salmeterol in maintaining improved lung function in B16-Arg/Arg patients with moderate persistent asthma. Safety profiles were comparable.
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J. Allergy Clin. Immunol. · Aug 2011
Randomized Controlled TrialTiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial.
Some patients with severe asthma remain symptomatic and obstructed despite maximal recommended treatment. Tiotropium, a long-acting inhaled anticholinergic agent, might be an effective bronchodilator in such patients. ⋯ The addition of once-daily tiotropium to asthma treatment, including a high-dose inhaled corticosteroid plus a long-acting β₂-agonist, significantly improves lung function over 24 hours in patients with inadequately controlled, severe, persistent asthma.
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J. Allergy Clin. Immunol. · Aug 2011
Urinary leukotriene E₄ levels identify children with tobacco smoke exposure at risk for asthma exacerbation.
Children with asthma exposed to secondhand smoke (SHS) might be at higher risk for severe exacerbations, but biomarkers of susceptibility to SHS exposure have not been previously reported. ⋯ Children exposed to SHS are at increased risk for severe asthma exacerbations, despite use of inhaled corticosteroids. uLTE₄ levels identify children exposed to SHS at high risk for asthma exacerbations.
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J. Allergy Clin. Immunol. · Aug 2011
Anaphylaxis during anesthesia in France: an 8-year national survey.
More attention should be paid to rare serious adverse events such as anaphylaxis to increase the safety of anesthesia. ⋯ The incidence of allergic reactions during anesthesia, estimated on a national basis, is higher than previously estimated. These results should be taken into account in the evaluation of the benefit-to-risk ratio of the various anesthetic techniques in individuals. The similar incidence of reactions according to sex before adolescence suggests a role for sex hormones in the increase of anaphylaxis observed in women.