Anesthesiology
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Randomized Controlled Trial Comparative Study Clinical Trial
Midlatency auditory evoked potentials and explicit and implicit memory in patients undergoing cardiac surgery.
A high incidence of intraoperative awareness during cardiac surgery has been reported. Midlatency auditory evoked potentials (MLAEP) have been used recently as an indicator of awareness. In the current study, memory for information presented during anesthesia was investigated using MLAEP as one experimental indicator in 45 patients scheduled for elective cardiac surgery. ⋯ When the early cortical potentials of MLAEP are preserved during general anesthesia, auditory information may be processed and remembered postoperatively by an implicit memory task.
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Randomized Controlled Trial Clinical Trial
Humans anesthetized with sevoflurane or isoflurane have similar arrhythmic response to epinephrine.
Anesthetics can alter the dose of exogenously administered epinephrine that causes cardiac arrhythmias. The purpose of this study was to test the hypothesis that in humans anesthetized with sevoflurane, the arrhythmic response to epinephrine is not different from the response in humans anesthetized with isoflurane. ⋯ Sevoflurane and isoflurane do not differ in their sensitization of the human myocardium to the arrhythmogenic effect of exogenously administered epinephrine.
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Impaired gas exchange is a major complication after cardiac surgery with the use of extracorporeal circulation. Blood gas analysis gives little information on underlying mechanisms, in particular if the impairment is multifactorial. In the current study we used the multiple inert gas technique with recordings of hemodynamics to analyze the separate effects of intrapulmonary shunt (QS/QT), ventilation-perfusion (VA/Q) mismatch, and low mixed venous oxygen tension on arterial oxygenation during cardiac surgery. ⋯ QS/QT is a major component of impaired gas exchange before, during, and after cardiac surgery. QS/QT increases after induction of general anesthesia, probably because of development of atelectasis. After separation from extracorporeal circulation, accumulation of extravascular lung water or further collapse of lung tissue may aggravate QS/QT. Postoperatively, oxygenation improves, possibly because of recruitment of previously nonventilated alveoli or resolution of extravascular lung water. During spontaneous breathing, additional mechanisms such as altered mechanics of the chest, perfusion of low-VA/Q regions, and decreased mixed venous oxygen tension may contribute to impaired gas exchange.