Anesthesiology
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Randomized Controlled Trial Clinical Trial
Effect of epidural epinephrine on the minimum local analgesic concentration of epidural bupivacaine in labor.
The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration in a 20-ml volume for epidural analgesia in the first stage of labor. The aim of this study was to determine the local anesthetic-sparing efficacy of epidural epinephrine by its effect on the MLAC of bupivacaine. ⋯ The addition of epidural epinephrine 1:300,000 (66 microg) resulted in a significant 29% reduction in the MLAC of bupivacaine. Coincident reductions in fetal heart rate and maternal blood pressure were also observed that were not clinically significant.
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Comment Letter Comparative Study
Do sevoflurane and desflurane differ in upper airway reactivity?