Anesthesiology
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Liver damage by ischemia and reperfusion injury is a risk factor for morbidity and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury by increasing inspiratory oxygen from 21 to 60% in the postoperative period were investigated in mice. ⋯ Liver injury after ischemia was significantly aggravated by hyperoxia as a consequence of immune cell-mediated oxidative burst. Further studies are needed to elucidate whether routine delivery of high inspirational oxygen concentrations postoperatively should be limited.
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Editorial Biography Historical Article
From Park Ridge to Schaumburg to the World Wide Web: The Wood Library-Museum of Anesthesiology.
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Editorial Review
Perioperative Management of Elderly Patients with Hip Fracture.