Anesthesiology
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The authors describe the preclinical pharmacological properties of GAL-021, a novel peripheral chemoreceptor modulator. ⋯ GAL-021 behaved as a breathing control modulator in rodents and nonhuman primates and diminished opioid-induced respiratory depression without compromising opioid analgesia. It acted predominantly at the carotid body, in part by inhibiting KCa1.1 channels. Its preclinical profile qualified the compound to enter clinical trials to assess effects on breathing control disorders such as drug (opioid)-induced respiratory depression and sleep apnea.
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Historical Article
Licorice-flavored Morphine for Babies: Winchell's Teething Syrup.