Anesthesiology
The most recent articles from:
Anesthesiology
-
Emerging evidence indicates that cyclic nucleotide phosphodiesterases exert distinct functions in pain processing and that targeting phosphodiesterases might be a novel strategy for pain relief. This study hypothesized that the phosphodiesterase isoform phosphodiesterase 10A (PDE10A) might be a target for analgesic therapy. ⋯ Collectively, the data support the idea that PDE10A is a suitable target for the development of efficacious analgesic drugs.