Anesthesiology
The most recent articles from:
Anesthesiology
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Comment Letter
Self-reported Race/Ethnicity and Occult Hypoxemia: Comment.
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Clinical Trial
Population pharmacokinetics of intranasal dexmedetomidine in infants and young children.
Intranasal dexmedetomidine provides noninvasive, effective procedural sedation for pediatric patients, and has been widely used in clinical practice. However, the dosage applied has varied fourfold in pediatric clinical studies. To validate an appropriate dosing regimen, this study investigated the pharmacokinetics of intranasal dexmedetomidine in Chinese children under 3 yr old. ⋯ The pharmacokinetic characteristics of intranasal dexmedetomidine were evaluated in Chinese pediatric patients aged between 3 and 36 months. An evidence-based dosing regimen at 2 µg · kg-1 could achieve a preset therapeutic threshold of mild to moderate sedation that lasted for up to 2 h.