Anesthesiology
The most recent articles from:
Anesthesiology
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Comparative Study
Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine.
To improve understanding of the respiratory behavior of oliceridine, a μ-opioid receptor agonist that selectively engages the G-protein-coupled signaling pathway with reduced activation of the β-arrestin pathway, the authors compared its utility function with that of morphine. It was hypothesized that at equianalgesia, oliceridine will produce less respiratory depression than morphine and that this is reflected in a superior utility. ⋯ These data indicate a favorable oliceridine safety profile over morphine when considering analgesia and respiratory depression over the clinical concentration range.