Clinica chimica acta; international journal of clinical chemistry
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Atherosclerosis is regarded as a lipid-driven chronic inflammatory disease. A variety of immune cells, including B1 cells, play an important role in the occurrence and development of atherosclerosis. ⋯ Accumulating evidence has shown that T15/E06 can protect against atherosclerosis by blocking macrophage lipid uptake, inhibiting vascular inflammation, and promoting apoptotic cell clearance. In this review, we describe the structure, functions and regulation of T15/E06 and summarize the latest advance regarding its atheroprotective effect.
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Human epididymis protein 4 (HE4) has been recognized as a biomarker which elevated in various diseases. The aim of this study was to evaluate the value of serum HE4 in pulmonary tuberculosis (PTB). ⋯ Elevated serum HE4 concentration could be used as a biomarker for the diagnosis and assessment of disease severity in PTB.
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Fabry disease (FD) is a genetic disorder caused by defective α-galactosidase-A enzyme due to mutations in the GLA gene. A reliable diagnosis in classical FD males can be made by measuring the enzyme activity while diagnosing classical FD females and non-classical FD patients requires mutation analysis. Plasma globotriaosylsphingosine (Lyso-Gb3) has progressively gained more importance as a diagnostic biomarker for FD in recent years. Having another biomarker to complement plasma Lyso-Gb3 will increase the diagnostic accuracy in the era of mass screening, and also precision medicine. This study aims to highlight the clinical utility of the total concentration of urinary Lyso-Gb3 plus its analogues in diagnosing FD. ⋯ Our study findings support that the total concentration of Lyso-Gb3 plus its analogues in urine is specific to FD and may provide extra diagnostic utility for both classical and non-classical FD patients.