Neuropsychologia
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We introduce an approach based on fast periodic oddball stimulation that provides objective, high signal-to-noise ratio (SNR), and behavior-free measures of the human brain's discriminative response to complex visual patterns. High-density electroencephalogram (EEG) was recorded for human observers presented with 60s sequences containing a base-face (A) sinusoidally contrast-modulated at a frequency of 5.88 Hz (F), with face size varying every cycle. Different oddball-faces (B, C, D...) were introduced at fixed intervals (every 4 stimuli = F/5 = 1.18 Hz: AAAABAAAACAAAAD...). ⋯ Face inversion or contrast-reversal did not affect the basic 5.88 Hz periodic response over medial occipital channels. However, these manipulations substantially reduced the 1.18 Hz oddball discrimination response over the right occipito-temporal region, indicating that this response reflects high-level processes that are partly face-specific. These observations indicate that fast periodic oddball stimulation can be used to rapidly and objectively characterize the discrimination of visual patterns and may become invaluable in characterizing this process in typical adult, developmental, and neuropsychological patient populations.
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The involvement of the hippocampus (HC) in episodic memory is well accepted; however it is unclear how each subfield within the HC contributes to memory function. Recent magnetic resonance imaging (MRI) studies suggest differential involvement of hippocampal subfields and subregions in episodic memory. However, most structural MRI studies have examined the HC subfields within a single subregion of the HC and used specialised experimental memory paradigms. ⋯ In general, anterior subregion volumes (HC head) correlated with verbal memory, while some anterior and many posterior HC subregion volumes (body and tail) correlated with visual memory scores (DE-Spatial, DE-Content). In addition, while verbal memory showed left-lateralized associations with HC volumes, visual memory was associated with HC volumes bilaterally. This the first study to examine the associations between hippocampal subfield volumes across the entire hippocampal formation with performance in a set of standard memory tasks.